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The onset is usually with pain on eye movement in one eye and subacute optic neuritis pdf visual loss. the diagnosis of optic neuritis is based on a constellation of symptoms and signs. it is highly associated with multiple sclerosis ( ms). describe the approach to establishing the diagnosis describe the etiology of this disease inflammatory demyelination of the optic nerve, either idiopathic or related to multiple sclerosis ( ms) define the relevant aspects of epidemiology of the disease typically age 20- 50 years, but cases may occur outside this range. while optic neuritis is frequently associated with multiple sclerosis ( ms), the causes of optic neuritis are protean. optic neuritis, or inflammation of the optic nerves, is a frequent cause of acute optic nerve injury in children and adults. one- third of patients with optic neuritis have a mildly edematous optic disc. optic pdf neuritis is the presenting feature of ms in 15 to 20 percent of patients and occurs in 50 percent at some time during the course of their illness [ 1- 4 ]. optic neuritis i. in unilateral optic neuritis, the direct pupillary light optic neuritis pdf reflex is weaker in the affected eye.
pathophysiology optic neuritis ( on) is one manifestation of central nervous system inflammation with resultant demyelination. introduction optic neuritis is an inflammatory, demyelinating condition that causes acute, usually monocular, visual loss. recurrent episodes of on indicate a propensity toward developing more generalized diseases [ 7] including ms, neuromyelitis pdf optica spectrum disorders ( nmosc), and myelin oligodendrocyte glycoprotein- igg ( mog) [ 8].
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